Nuclear receptors and the Warburg effect in cancer
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منابع مشابه
Nuclear receptors and the Warburg effect in cancer
In 1927 Otto Warburg established that tumours derive energy primarily from the conversion of glucose to lactic acid and only partially through cellular respiration involving oxygen. In the 1950s he proposed that all causes of cancer reflected different mechanisms of disabling cellular respiration in favour of fermentation (now termed aerobic glycolysis). The role of aberrant glucose metabolism ...
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One of the first studies on the energy metabolism of a tumour was carried out, in 1922, in the laboratory of Otto Warburg. He established that cancer cells exhibited a specific metabolic pattern, characterized by a shift from respiration to fermentation, which has been later named the Warburg effect. Considerable work has been done since then, deepening our understanding of the process, with co...
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Department of Chemistry, University of Pennsylvania, USA Department of Physiology and Integrated Biosystems, College of Medicine, Inje University, Busan, Korea Systems Immunology Laboratory, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan Department of Internal Medicine, College of Medicine, Inje University and Busan Paik Hospital Organ Transplantation Center, Busan, Kor...
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A remarkable trademark of most tumors is their ability to break down glucose by glycolysis at a vastly higher rate than in normal tissues, even when oxygen is copious. This phenomenon, known as the Warburg effect, enables rapidly dividing tumor cells to generate essential biosynthetic building blocks such as nucleic acids, amino acids, and lipids from glycolytic intermediates to permit growth a...
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نتایج این مطالعه نشان می دهد که مقدار کلسیم (یونیزه و تام)، منیزیم و فسفر به طور معنی داری تغییر پیدا کرد به جزء مقدار کلسیم تام و منیزیم در روش داخل عضلانی که تغییر معنی داری نداشته است. بر اساس نتایج این مطالعه می توان نتیجه گیری کرد که اکسی تتراساکلین بر روی مقادیر سرمی کلسیم و منیزیم تأثیر می گذارد باید مقدار این کاتیون ها در بیماران، در هنگامی که اکسی تتراسایکلین استفاده می شود مورد توجه ق...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2014
ISSN: 0020-7136,1097-0215
DOI: 10.1002/ijc.29012